Endometrial Receptivity Analysis: The Importance of ERA Test in Assisted Reproduction


In today’s world, Assisted Reproductive Technologies are the greatest boon to couples with infertility issues. There are so many advanced diagnostic procedures and treatment options that thousands of infertile couples around the globe can conceive. Today we will talk about one such excellent test known as endometrial receptivity analysis. This test is crucial in IVF as it allows fertility experts to study the patient’s endometrium and endometrial lining. This step can be crucial in your IVF cycle to find out if it is in a suitable state to facilitate embryo implantation.

But how much does endometrial receptivity analysis cost and how can it benefit you? What are the success rates of endometrial receptivity analysis? Let’s answer all your questions about ERA.

Definition of Endometrial Receptivity Analysis

In simple words, ERA or endometrial receptivity analysis is one of the latest diagnostic procedures that can help determine if a woman’s endometrial cavity is prepared for embryo implantation. As it identifies the optimal time to proceed with frozen embryo transfer, having a successful implantation becomes less challenging.

ERA Procedure

ERA endometrial receptivity analysis is a painless procedure which involves the following two steps:

  1. endometrial biopsy
  2. gene sequencing

During endometrial biopsy, a tissue sample is taken from the endometrial lining. After analyzing the endometrium receptivity result, the doctor determines whether the uterine lining is ready or not. ERA is also an outpatient procedure and sedation is not required. It will be done in less than 5 minutes; after that, you can return home without discomfort.

Who Is the Right Candidate for Endometrial Biopsy?

Healthcare professionals usually recommend ERA biopsy to women who are undergoing treatment for infertility and their earlier IVF circles have resulted in failures. In addition to the reproductive medicines prescribed by your doctor, ERA might also be needed. If someone had several pregnancy losses or miscarriages, then also ERA can be helpful.

However, ERA is not that important for people in the initial stage of their IVF (in vitro fertilization) journey. If you are still considering ERA, you should discuss it with your IVF doctor to choose what’s best for you.

The Success Rate of ERA

ERA technology aims to analyze the overall health of the embryo to understand the right time for implantation on the uterus lining. Its application may drastically better embryo implantation, especially for people who have experienced recurrent implantation failure. So, the ERA test is done by doctors during reproductive treatments such as ICSI, FET, and IVF.

As far as the success rate of ERA is concerned, it is 95% (even in women who have dealt with implantation failure repeatedly). To maximize the chances of achieving success, you should also choose a reputed fertility clinic that has experienced doctors.

To Sum Up

Hence, it goes beyond saying that endometrial receptivity analysis enhances the outcome of IVF pregnancy by showing when the endometrium is receptive and when it is non-receptive. That explains why high implantation improvement is noticeable.