What is platelet-rich plasma (PRP) in IVF?

prp in ivf

In vitro, fertilization (IVF) and other fertility methods using platelet-rich plasma (PRP), is a cutting-edge medical technique that is becoming more popular in many areas. Platelets from a patient’s blood are separated and gathered for platelet-rich plasma (PRP). These platelets are then put back into certain areas to help heal, grow, and regenerate tissue. This regenerative treatment has shown promise in improving the chances of getting pregnant and helping with some reproductive problems.

Who Should Get PRP?

PRP Therapy can help people who are having trouble getting pregnant for several reasons. Here are some situations where PRP might be useful in pregnancy outcomes:

  • Low Eggs: When a woman only has a few healthy eggs left in her ovaries, she may choose PRP to make her current follicles healthier and better.
  • Thin Endometrial Lining: PRP can help the endometrial lining grow, which is important for egg implantation because the lining isn’t thick enough.
  • Recurrent Implantation Failure (RIF): Couples who have had multiple failed IVF rounds may want to try PRP as an extra treatment to help the embryos stick.
  • Male Factor Infertility: PRP can be used to help men who are having trouble getting pregnant because it may improve the quality and function of their sperm.
  • Infertility That Can’t Be Explained: If the reason for infertility is still unknown, PRP preparation may be a good way to improve general reproductive health.

How does PRP work in IVF?

When PRP is used in vitro, the process is broken down into several steps:

  • Blood Collection: A common method is used to take a small amount of blood from the patient, usually from the arm.
  • Centrifugation: The blood is then put through a centrifuge, a special machine that spins quickly to sort the blood’s parts. In this step, the platelet-rich part of the blood is separated from the red blood cells, plasma, and other parts of the blood.
  • Platelet Activation: Once the platelet-rich part has been separated, calcium chloride or a related material is used to activate it. Platelets release growth factors when they are activated. These factors are needed for tissue repair and renewal.
  • Injection: The PRP is carefully injected into the target area after it has been triggered. In IVF, this could be the ovaries to help the follicles grow or the uterus to help the lining of the uterus.
  • Monitoring and IVF Procedures: After receiving PRP, patients usually go through normal IVF procedures, such as controlled ovarian stimulation, egg removal, fertilization, and embryo transfer.

How is PRP used in other ways to Treat Infertility?

Besides IVF, PRP has been used in other fertility methods as well:

  • Ovarian Rejuvenation: PRP can be put into the ovaries to wake up sluggish cells and improve the quality of eggs. This may help women whose ovarian reserve is low the most.
  • Male infertility: Putting PRP into the testes or seminal vesicles, which are parts of a man’s reproductive system, may improve the quality and function of sperm. This could make it easier for the man to get pregnant naturally or with the help of assisted reproductive methods.
  • Uterine Health: PRP can be put on the lining of the uterus to make the endometrium thicker and make it easier for embryos to attach.
  • Polycystic Ovary Syndrome (PCOS) Treatment: PRP  may help women with PCOS control their monthly patterns and make ovulation happen more often.
  • Fertility Preservation: The use of PRP helps people who are getting cancer treatments keep their fertility because it may protect the ovaries from damage caused by radiation or chemotherapy.

Does PRP make the Endometrium Thicker?

Yes, PRP has shown promise in making the endometrium thicker, which is an important part of both IVF and normal conception where embryos can be implanted. Platelets in PRP release growth factors that help endometrial tissue grow back. This makes the lining of the uterus stronger and more responsive.

Researchers and clinical studies have shown that injecting PRP into the lining of the uterus can make the endometrium much thicker. For people who have trouble getting pregnant because their uterine linings are too thin, this method can be a helpful addition to their treatment plan.

How much does PRP cost for IVF?

A single PRP treatment for IVF can cost anywhere from 10,000 to 25,000 rupees or even more. It’s important to talk to the fertility center you choose about their prices and make sure you understand what’s included in the price.

How often PRP works in IVF

There is more and more proof that PRP can help with IVF, but success rates can be different. People who are having trouble getting pregnant should talk to their fertility doctor to find out if PRP is a good choice for them.

As in any other place, the success rate of PRP in Ritu IVF depends on several things, including:

  • Patient-Specific Factors: Success rates can be affected by the patient’s age, general health, pregnancy problems, and how well they respond to PRP.
  • Clinic and Medical Team: The fertility clinic’s knowledge and the medical team’s skill at performing PRP treatments are very important for getting good results.
  • Timing: The success rate can be affected when PRP is given during the IVF cycle and by the specific goals of the fertility treatment (for example, increasing the quality of the eggs or the thickness of the endometrium).
  • As Part of Other methods: PRP is often used along with standard IVF methods. Success rates can be changed by how well PRP and IVF work together.
  • Ideas of the Patient: Patients need to have realistic ideas about how PRP might work in IVF. Success rates may not make it certain that you will get pregnant, but they can make it more likely.

Why PRP is Good for IVF

When used in IVF treatments, PRP in the treatment may have several perks, including:

Better Egg Quality: PRP can make eggs better, which is especially helpful for older people or women whose ovarian reserve has been reduced.

Better Endometrial Lining: PRP can help the endometrial lining grow, which raises the chances of an egg implanting successfully.

Natural Method: Because PRP comes from the patient’s blood. It is a natural and autologous treatment with almost no risk of side effects or allergic responses.

Customized Treatment: PRP can be changed to help with certain pregnancy rate problems, which makes it a personalized treatment choice.

Possible Cost Savings: PRP does raise the overall cost of IVF. It may raise the chances of success, which means that one run of IVF may not be needed as often.

Minimally Invasive: PRP treatments are not very invasive, and patients usually don’t have to take much time off afterward.

The Risks of using PRP in IVF

Most people think that the effect of PRP treatment is safe as long as it is done by a trained medical worker using clean methods. Since PRP comes from the patient’s blood, there is almost no chance of an allergic response or disease spreading.

PRP for IVF comes with some risks, just like any other medical procedure:

  • Illness: There is a very small chance of getting an illness where the shot was given. To lower this chance as much as possible, strict clean methods should be used.
  • Pain or Discomfort: Some people may feel mild pain, swelling, or discomfort by PRP injection at the injection site. This is usually only temporary.
  • Bruising: Some people may get bruises where they got the shot, but they usually go away on their own.
  • Allergic responses: Allergic responses to PRP components are not common, but they can happen. Patients should let their doctor know about any issues they know about.
  • No Promise of Success: It’s important to remember that PRP is not a surefire way to fix pregnancy problems.

Things can go wrong, and the treatment might not work for everyone.

One thing to think about is the cost of PRP, which could be a risk if it doesn’t improve fertility as planned.

People who are thinking about using PRP in IVF should talk to their doctor about these risks.

Is it Possible to Get Pregnant after PRP?

It is possible to become pregnant after using PRP treatment along with IVF. PRP is often used along with IVF to improve the chances of getting pregnant. It can make eggs better, speed up the growth of the uterus lining, and help with certain reproductive problems, all of which can raise the chances of getting pregnant. But it’s important to remember that even though PRP can increase the chances of success with IVF. It doesn’t promise pregnancy because everyone’s situation is different.

Does PRP Hurt?

Most people don’t find PRP treatments painful, but the amount of pain can be different for each person. A lot of times, patients say it feels like a light pinprick or pressure at the injection site. Most of the time, the pain is short-lived and easy to deal with.

To make PRP treatments less painful, doctors may use external anesthetics or calming drugs at the injection site. The use of tiny needles and the skill of the healthcare worker can also make the experience more relaxing.

Does PRP help with Moving Embryos?

In several ways, PRP can help with the egg transfer process during IVF:

Better uterine Lining: PRP can help the uterine lining in the uterus grow and get thicker. The uterus must be healthy and open to the embryo for egg implantation to go well.

Better Uterine Environment: PRP shots can make the uterus a better place for a baby to settle by increasing blood flow and encouraging tissue regrowth.

Less likely to fail: People who have had repeated implantation failure (RIF) may benefit from PRP. Because it can help fix underlying problems, making it more likely that the next implantation will work.

Customized Treatment: PRP can be changed to address specific fertility issues. Which makes it a useful tool for making sure that embryo transfers go well.

While PRP can help with egg transfer, its use is usually decided on an individual basis, taking into account the patient’s unique fertility issues and goals. A fertility expert should be consulted before adding PRP to the IVF process so that they can properly evaluate the patient’s wants and situation.


Platelet-rich plasma (PRP) is a flexible and hopeful healing method that can be used in fertility treatments. It gives people who are having trouble getting pregnant hope. Even if they have problems like low ovarian reserve or thin uterine linings. When used correctly, PRP can increase the chances of IVF success, boost the quality of sperm, and help people who are having trouble getting pregnant. PRP can also help with healing in other medical areas. This makes it an exciting area of current study and new ideas in reproductive health and other areas as well.

FAQ Regarding PRP Treatment

Does PRP increase AMH?

PRP may enhance ovarian function, although it seldom raises AMH levels. AMH measures ovarian reserve but not egg quality or reproduction.

What hurts most during IVF?

Many find egg extraction the most painful phase of IVF. This method removes mature eggs from the ovaries using a needle, which might hurt or swell.

Does PRP aid implanting?

Yes, PRP aids IVF implantation. Making the uterine lining thicker and more responsive is common. This helps the egg settle and improves delivery outcomes.

Does PRP increase follicles?

Sometimes PRP may enhance healthy cells. PRP may awaken latent ovarian follicles, causing more to develop during IVF. This improves egg retrieval and fertilization. How individuals respond to PRP varies.